News News

Models for human porphyrias: Have animals in the wild been overlooked?

Humans accumulate porphyrins in the body mostly during the course of porphyrias, diseases caused by defects in the enzymes of the heme biosynthesis pathway and that produce acute attacks, skin lesions and liver cancer. In contrast, some wild mammals and birds are adapted to accumulate porphyrins without injurious consequences. This study proposes to view such physiological adaptations as potential solutions to human porphyrias, and suggest certain wild animals as models. Given the enzymatic activity and/or the patterns of porphyrin excretion and accumulation, the fox squirrel, the great bustard and the Eurasian eagle owl may constitute overlooked models for different porphyrias. The Harderian gland of rodents, where large amounts of porphyrins are synthesized, presents an underexplored potential for understanding the carcinogenic/toxic effect of porphyrin accumulation. Investigating how these animals avoid porphyrin pathogenicity may complement the use of laboratory models for porphyrias and provide new insights into the treatment of these disorders. informacion[at] De Oliveira Neves & Galvan (2020) Models for human porphyrias: Have animals in the wild been overlooked? BioEssays. DOI 10.1002/bies.202000155
Average (0 Votes)

Latest News Latest News


When GPS tracking devices do not provide reliable information

When GPS tracking devices do not provide reliable information

New technological devices used for animal tracking have evolved at a tremendous speed. The new biologgers equipped with GPS and solar panels that download data using satellites or mobile networks seem unbeatable. They provide thousands of location of marked animals with meter precision and even in real time. But, do the data we collect provide an unbiased recall of what the animals have done?, of their movements?, of their behavior? The tracking data of Bearded vultures (Gypaetus barbatus) marked in the Pyrenees and the Cantabrian mountains with solar devices have been analyzed. They show that more locations do not always provide more information. The paper concludes that recorded locations should be analyzed carefully not to get a distorted picture of the Bearded vulture behavior. Tracking devices with solar panels depend on solar radiation to recharge their batteries. When insolation is low the devices do not fully recharge and more locations are lost. If this is not taken into account during data analysis we could have the false impression that the vultures move less at this time of year. This kind of tracking devices is essential for the Bearded vulture reintroduction project success. A tracking schedule that demands too many locations can cause the devices to run-out of battery, creating gaps in the data. The problem is that data are not lost at random: more locations are lost in winter than in summer; more are lost when vultures are in rugged versus flat areas; more when they are perched versus flying. Sometimes, complex interactions arise among behavioral and environmental factors creating difficult to correct biases. The GPS looses more locations when in a dynamic versus static state. This means that when the bird is flying the GPS requires more time to obtain a fix, but when perched the GPS loose fixes because an irregular topography precludes good visibility of the GPS satellite constellation. The biases in the locations that are lost determine that devices from different manufacturers may provide very different results on the daily proportion of time bearded vultures are on the wing. The researchers remark the importance of using devices that can be reprogrammed from a distance once deployed. In this way data acquisition can be readjusted to the amount of solar energy the device is able to harvest in the real environment. informacion[at] Silva at al (2017) Seasonal and circadian biases in bird tracking with solar GPS-tags. PLoS ONE