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Epigenetic regulation of host-parasite interactions in human malaria Human malaria is a mosquito-borne infectious disease caused by protozoan parasites of the genus Plasmodium, transmitted by mosquitoes of the genus Anopheles. Human malaria parasites have a complex life-cycle with two host: the human and the mosquito. Most of previous research has focused on the human compartment and mainly involved laboratory experiments in vitro, while we know little about the host-parasite interactions during the mosquito life-cycle. Both the parasite and the mosquito display plasticity in life-history traits like parasite virulence and mosquito resistance, as a result of the interaction and heterogeneity in their environments. Epigenetic processes provide mechanisms for fast and reversible phenotypic variation in the context of parasitic interactions. In this scientific context, my PhD project aims at applying various –omics approaches to study chromatin-associated transcriptional regulation underlying the adaptations between Plasmodium falciparum and their hosts. In a first section I will focus on the parasite, in particular how the P. falciparum regulates its genome to transit through different hosts and survive under variable within host environments. In the second section, I will present our work onto the role of epigenetic mechanisms underlying phenotypic and transcriptional responses of the mosquito, An. gambiae, to an infection by the human malaria parasite P. falciparum.

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