DisPersal of AntIbiotic Resistance and antibiotics in Water ecosystems and Influence on liveStock and aquatic - PAIRWISE
Dispersión de la Resistencia a los Antibióticos y los Antibióticos en ecosistemas acuáticos y su influencia en el ganado bovino y la vida silvestre acuática
Principal investigator
Andy J. Green
Financial institution
AEI y JPI Aquatic Pollutants 2020
Fecha de inicio
Fecha de fin
Code
PCI2021-121938
Department
Conservation Biology and Global Change
Researchers
National Veterinary Institute (SVA), the Department of Animal Health and Antimicrobial Strategies, Uppsala, Sweden; Norwegian Institute for Water Research (NIVA), the Department of Environmental Chemistry and Technology, Oslo, Norway; Linköping University (LiU), the Department of Biomedical and Clinical Sciences, Linköping, Sweden; National Research Institute for Rural Engineering, Water, and Forestry (INRGREF), the Department of Chemistry Laboratory for Water-Soil-Sludge, Ariana, Tunisia; Faculty of medicine Ibn Al-Jazzar Sousse (FMS), the Department of Microbiology, Sousse, Tunisia; Makerere University (MAK), the Department of Zoology, Entomology and Fisheries Sciences, Kampala, Uganda
Brief description
PAIRWISE propone investigar la resistencia antimicrobiana (RAM) en los ambientes acuáticos, la fauna salvaje y el ganado. PAIRWISE se centra en el estudio de la dinámica de dispersión de las bacterias resistentes a los antibióticos (BRA), los genes de resistencia a antibióticos (GRA) y los antibióticos (ATB) en ecosistemas acuáticos afectados por estaciones depuradoras de aguas residuales (EDARs), así como en el ganado y las aves asociadas a estos ambientes. Los objetivos generales son comprender: i) la dispersión de BRA, GRA y ATB en aguas superficiales más debajo de las EDARs, ii) el papel de las EDARs en la presencia de BRA y GRA en el ganado, iii) el papel de las aves acuáticas en la dispersión de BRA y GRA. Los temas abordados por PAIRWISE incluyen: los puntos de entrada y destino de BRA, GRA y ATB; la identificación de GRA y BRA útiles como indicadores; proporcionar una mejor comprensión sobre el destino y transporte de BRA, GRA y ATB dentro y entre ecosistemas acuáticos; y el papel de las aves acuáticas en estos eventos.
PAIRWISE evaluará la influencia de la RAM en ambientes agrícolas y mejorará la comprensión sobre la diseminación y el mantenimiento de la RAM en la interfaz entre humanos, fauna salvaje y ganado, con una perspectiva de One Health. Esto proporcionará un conocimiento fundamental para los responsables políticos, consumidores y usuarios, facilitando decisiones sobre estrategias de mitigación.
Antimicrobial resistance (AMR) in bacteria is one of the greatest threats to animal and human health, and is causing increasing costs for society.
PAIRWISE investigates AMR in aquatic environments, wildlife and livestock. The occurrence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in wildlife is a growing ecological problem. PAIRWISE focuses on dispersal dynamics of ARB, ARG and antibiotics (ATB) in aquatic environments affected by wastewater treatment plants (WWTPs), as well as livestock and birds associated with these environments. The overall goals are to understand the: i) dispersal of ARB, ARG and ATB in surface waters downstream of WWTPs, ii) role of WWTPs in carriage of ARB and ARG in livestock downstream, iii) role of aquatic birds in dispersal of ARB and ARG. Issues tackled by PAIRWISE include: entry points and fate of ARB, ARG and ATB; identification of ARGs and ARB useful as indicators; providing insight to fate and transport of ARB, ARG and ATB to, within and from aquatic ecosystems; and the role of aquatic birds in such events. PAIRWISE will assess the influence of AMR in agricultural settings and improve understanding of the dissemination and sustainment of AMR in the interface between humans, wildlife and livestock with a One Health perspective. It will provide vital knowledge for policy makers and end-users, facilitating decisions on mitigation strategies.
PAIRWISE evaluará la influencia de la RAM en ambientes agrícolas y mejorará la comprensión sobre la diseminación y el mantenimiento de la RAM en la interfaz entre humanos, fauna salvaje y ganado, con una perspectiva de One Health. Esto proporcionará un conocimiento fundamental para los responsables políticos, consumidores y usuarios, facilitando decisiones sobre estrategias de mitigación.
Antimicrobial resistance (AMR) in bacteria is one of the greatest threats to animal and human health, and is causing increasing costs for society.
PAIRWISE investigates AMR in aquatic environments, wildlife and livestock. The occurrence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in wildlife is a growing ecological problem. PAIRWISE focuses on dispersal dynamics of ARB, ARG and antibiotics (ATB) in aquatic environments affected by wastewater treatment plants (WWTPs), as well as livestock and birds associated with these environments. The overall goals are to understand the: i) dispersal of ARB, ARG and ATB in surface waters downstream of WWTPs, ii) role of WWTPs in carriage of ARB and ARG in livestock downstream, iii) role of aquatic birds in dispersal of ARB and ARG. Issues tackled by PAIRWISE include: entry points and fate of ARB, ARG and ATB; identification of ARGs and ARB useful as indicators; providing insight to fate and transport of ARB, ARG and ATB to, within and from aquatic ecosystems; and the role of aquatic birds in such events. PAIRWISE will assess the influence of AMR in agricultural settings and improve understanding of the dissemination and sustainment of AMR in the interface between humans, wildlife and livestock with a One Health perspective. It will provide vital knowledge for policy makers and end-users, facilitating decisions on mitigation strategies.