Dramatic loss of biodiversity in the last two decades has been associated with human activities. Yet, we understand little of the mechanisms that enable species persistence to anthropogenic environmental changes over evolutionary time. Here, I present ecological and evolutionary responses of a population of Daphnia magna to multiple anthropogenic stressors over six decades. I studied the phenotypic and molecular responses that enabled a population of D. magna to persist across major pollution events, including pesticides and increase of temperature. In this talk I present some of my most interesting findings